Part 2 of season 2 of the anime Kusuriya no Hitorigoto (The Apothecary Diaries) had its opening sequence revealed without credits. It premieres today, April 4, 2025.
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Titled “Kusushiki”, by the band Mrs. GREEN APPLE. This new phase of the anime officially begins with episode 13, which airs today, April 4th, at 11:40 AM (Japan time). The animation is by TOHO Animation and STUDIO × OLM.
On the anime's official website, vocalist Motoki Ohmori commented on how honored the band feels to contribute to such a beloved work in Japan and around the world. The inspiration for "Kusushiki" came from the Japanese word "shi," which can mean both "medicine" and something "mysterious and wonderful."
Synopsis:
Maomao, the daughter of a pharmacist with an unusual fascination for poisons and remedies, and Jinshi, a handsome and enigmatic eunuch, face even more complex mysteries within the imperial court! With the confirmation of the pregnancy of the emperor's favorite consort, Lady Gyokuyo, Maomao returns to the Jade Palace as her poison taster. While she lives vigilantly to prevent further attacks on the consort and the imperial heir, several other issues begin to arise: the arrival of a new consort, Lady Loulan, daughter of a powerful minister from the era of the former emperor; an unsolved case that put Jinshi's life at risk; and the unknown whereabouts of the suspect, Sui Rei. However, amidst this tense atmosphere, foreign merchants and an emissary with absurd demands arrive at the palace.
However, Kusuriya no Hitorigoto (Diaries of an Apothecary) began its publication in October 2011 in Shousetsuka ni Narou. Eventually, the novel had two manga adaptations, the first by Nekokurage published in Big Gangan and the second in Sunday Gene-X.
Source: Official Website